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Effects of anti-motion sickness drugs on motion sickness in rats.

Abstract
Pica, the eating of nonnutritive substances such as kaolin, can be induced by rotation in rats. We used this rotation-induced pica as a behavioral index of motion sickness in rats and examined whether diphenhydramine, methamphetamine and scopolamine, which are anti-motion sickness drugs for humans, are effective for reducing motion sickness in rats. Intraperitoneal injection of diphenhydramine or methamphetamine suppressed the rotation-induced kaolin intake of rats. Intraperitoneal injection of scopolamine had no effect on the rotation-induced kaolin intake, but its transdermal administration reduced this kaolin intake. These findings show that human anti-motion sickness drugs also prevent motion sickness in rats. Since the pharmacological mechanisms for preventing motion sickness in rats and humans are similar, we conclude that rats are a suitable animal model for use in studies on putative anti-motion sickness drugs.
AuthorsM Morita, N Takeda, T Kubo, A Yamatodani, H Wada, T Matsunaga
JournalORL; journal for oto-rhino-laryngology and its related specialties (ORL J Otorhinolaryngol Relat Spec) Vol. 50 Issue 5 Pg. 330-3 ( 1988) ISSN: 0301-1569 [Print] Switzerland
PMID3186231 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Kaolin
  • Methamphetamine
  • Diphenhydramine
  • Scopolamine
Topics
  • Animals
  • Diphenhydramine (therapeutic use)
  • Kaolin
  • Male
  • Methamphetamine (therapeutic use)
  • Motion Sickness (drug therapy)
  • Pica (drug therapy, etiology)
  • Rats
  • Rats, Inbred Strains
  • Rotation (adverse effects)
  • Scopolamine (therapeutic use)

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