Cyclo(His-Pro) and the development of tolerance to the hypothermic effect of ethanol.

Abstract

Acute intraperitoneal administration of ethanol to rats causes a dose-dependent transient hypothermia. On repeated exposure, however, rats develop tolerance to hypothermic effects of ethanol. Cyclo(His-Pro), an endogenous brain peptide, modifies both acute and chronic themomodulatory effects of alcohol. For example, a) acute pretreatment of rats with increasing amounts of cyclo(His-Pro) produces a progressive decrease in ethanol hypothermia, and b) chronic cyclo(His-Pro) administration augments the development of tolerance to hypothermic effects of alcohol. While the mechanism of cyclo(His-Pro) action is not clear, these data are interpreted to suggest that this peptide may play important roles in ethanol intoxication, preference, tolerance, and/or addiction.

• Authors: C Prasad, P Balasubramanian
• Journal: Neuropeptides (Neuropeptides) 1988 Aug-Sep Vol. 12 Issue 2 Pg. 75-9 ISSN: 0143-4179 [Print] Netherlands
• PMID: 3185871 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Peptides, Cyclic
• Piperazines
• Ethanol
• Acetaldehyde
• histidyl-proline diketopiperazine

Topics

• Acetaldehyde (toxicity)
• Animals
• Drug Tolerance
• Ethanol (toxicity)
• Hypothermia, Induced
• Male
• Peptides, Cyclic (pharmacology)
• Piperazines (pharmacology)
• Rats
• Rats, Inbred Strains