Data mining analysis of the PP2A cell cycle axis in mesothelioma patients.

Abstract

Mesothelioma is an aggressive tumor that affects thousands of people every year. The therapeutic options for patients are limited; hence, a better understanding of mesothelioma biology is crucial to improve patient survival. To find new molecular targets and therapeutic strategies related to the protein phosphatase 2A (PP2A) network, we analyzed the gene expression of known PP2A inhibitors in mesothelioma patient samples. Our analysis disclosed a general overexpression of all PP2A-negative regulators in mesothelioma patients. Moreover, the expression of ANP32E and CIP2A genes, increased in 16% and 11% of cases, positively correlates with the ones of all the other PP2A regulators and the ones of the main cyclins and CDKs, suggesting the existence of a feed-forward loop that might contribute to the mesothelioma progression via PP2A inactivation. Overall, our study indicates the existence of a strategic and targetable axis between PP2A inhibitors (ANP32E and CIP2A) and cell cycle regulators (cyclin B2/CDK1) and provides a valuable rationale for using a personalized combinational therapy approach to improve mesothelioma patient survival.

• Authors: Raffaella Pippa, Silvia Boffo, Maria D Odero, Antonio Giordano
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 235 Issue 6 Pg. 5284-5292 (06 2020) ISSN: 1097-4652 [Electronic] United States
• PMID: 31858592 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 Wiley Periodicals, Inc.

Chemical References

• ANP32E protein, human
• Autoantigens
• CIP2A protein, human
• Cell Cycle Proteins
• Cyclin B2
• Intracellular Signaling Peptides and Proteins
• Membrane Proteins
• Molecular Chaperones
• CDC2 Protein Kinase
• Protein Phosphatase 2

Topics

• Autoantigens (genetics)
• CDC2 Protein Kinase (genetics)
• Cell Cycle (genetics)
• Cell Cycle Proteins (genetics)
• Cell Division (genetics)
• Cell Line, Tumor
• Cyclin B2 (genetics)
• Data Mining
• Female
• Gene Expression Regulation, Neoplastic (drug effects)
• Humans
• Intracellular Signaling Peptides and Proteins (genetics)
• Male
• Membrane Proteins (genetics)
• Mesothelioma (drug therapy, genetics, immunology, pathology)
• Molecular Chaperones (genetics)
• Molecular Targeted Therapy
• Phosphorylation (drug effects)
• Protein Phosphatase 2 (antagonists & inhibitors, genetics)
• Signal Transduction (drug effects)