Abstract | BACKGROUND: METHODS:
Tumor tissues and adjacent healthy tissues were collected from gastric cancer patients. Expression of PTCSC3 and lncRNA Linc-pint in these tissues was analyzed by RT-qPCR. The interaction between PTCSC3 and Linc-pint was analyzed by overexpression experiments. Cell proliferation and stemness were analyzed by CCK-8 assay and cell stemness assay, respectively. RESULTS: PTCSC3 and lncRNA Linc-pint were both downregulated in tumor tissues than in adjacent healthy tissues of gastric cancer patients. Low levels of PTCSC3 and Linc-pint were closely correlated with poor survival. PTCSC3 and Linc-pint overexpression inhibited tumor growth and cancer cell stemness, while Linc-pint knockdown played an opposite role an attenuated the effects of PTCSC3 overexpression. Expression levels of PTCSC3 and Linc-pint were significantly correlated in tumor tissues but not in adjacent healthy tissues. Overexpression of PTCSC3 and Linc-pint upregulated the expression of each other. CONCLUSION:
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Authors | Lei Hong, Haijuan Wang, Junyan Wang, Suju Wei, Fan Zhang, Jing Han, Yan Liu, Minting Ma, Chengyuan Liu, Yu Xu, Da Jiang |
Journal | Cancer management and research
(Cancer Manag Res)
Vol. 11
Pg. 10393-10399
( 2019)
ISSN: 1179-1322 [Print] New Zealand |
PMID | 31849528
(Publication Type: Journal Article)
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Copyright | © 2019 Hong et al. |