Abstract |
Lung cancer, especially non-small cell lung cancer (NSCLC), is the most common malignant tumor associated with poor prognosis. Angiogenesis plays a vital role in NSCLC, and could be used in tumor staging and therapy evaluation. CD93 ( C1q receptor) is reportedly a key regulator of tumor angiogenesis. In the present study, the efficacy and specificity of a 125I-labeled CD93-specific monoclonal antibody (125I-anti-CD93 mAb) in detecting NSCLC xenografts were analyzed, and the association between CD93 expression and 125I-anti-CD93 mAb uptake by tumors was evaluated. The targeting ability of 125I-anti-CD93 mAb enabled its rapid, continuous and highly specific accumulation in CD93-expressing tumors in vivo. These results revealed the potential applicability of 125I-anti-CD93 mAb for non-invasive imaging diagnosis of CD93-positive NSCLC.
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Authors | Weiwei Liu, Chao Zhang, Hui Cao, Dai Shi, Shanshan Zhao, Ting Liang, Guihua Hou |
Journal | Oncology letters
(Oncol Lett)
Vol. 18
Issue 6
Pg. 6413-6422
(Dec 2019)
ISSN: 1792-1074 [Print] Greece |
PMID | 31819775
(Publication Type: Journal Article)
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Copyright | Copyright: © Liu et al. |