Abstract | BACKGROUND: METHODS: We included 535 patients with COPD from the KOLD cohort. Serum bilirubin levels and various clinical parameters, such as lung function, 6-min walking (6 MW) distance, quality of life (QoL), and exacerbation, were evaluated annually; their association was analyzed using generalized estimating equations and the linear mixed model. RESULTS: Among 535 patients, 345 (64.5%) and 190 (35.5%) were categorized into Global Initiative for Chronic Obstructive Lung Disease ( GOLD) I-II and GOLD III-IV groups, respectively. 6 MW distance was positively associated with serum bilirubin levels, especially in the GOLD I-II group (estimated mean = 41.5). Among QoL indexes, the COPD assessment test score was negatively associated with serum bilirubin levels only in the GOLD I-II group (estimated mean = - 2.8). Higher serum bilirubin levels were independently associated with a higher number of acute exacerbation in the GOLD III-IV group (estimated mean = 0.45, P = 0.001). Multivariate analysis revealed that lung function and mortality were not associated with serum bilirubin levels. CONCLUSIONS: Higher serum bilirubin levels were associated with a longer 6 MW distance and better QoL, especially in the GOLD I-II group, whereas they were related to a higher risk of acute exacerbation, especially in the GOLD III-IV group. Bilirubin levels may represent various conditions in COPD.
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Authors | Ah Young Leem, Young Sam Kim, Ji-Hyun Lee, Tae-Hyung Kim, Ha Yan Kim, Yeon Mok Oh, Sang Do Lee, Ji Ye Jung |
Journal | Respiratory research
(Respir Res)
Vol. 20
Issue 1
Pg. 279
(Dec 09 2019)
ISSN: 1465-993X [Electronic] England |
PMID | 31818285
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
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Topics |
- Aged
- Bilirubin
(blood)
- Biomarkers
(blood)
- Disease Progression
- Exercise Tolerance
- Female
- Forced Expiratory Volume
- Humans
- Lung
(physiopathology)
- Male
- Middle Aged
- Prognosis
- Pulmonary Disease, Chronic Obstructive
(blood, diagnosis, physiopathology, psychology)
- Quality of Life
- Republic of Korea
- Risk Factors
- Severity of Illness Index
- Time Factors
- Up-Regulation
- Vital Capacity
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