| Abstract | Amiodarone-induced bilateral diffuse pulmonary fibrosis developed in a 47-year-old woman with idiopathic hypertrophic subvalvular aortic stenosis who had been treated with amiodarone (Cordarex), 300 mg daily for about 18 months. Although the drug was discontinued and cortisone treatment begun, the pulmonary fibrosis did not regress. When gentamicin (Refobacin) and cefotaxime (Claforan) were administered for suspected fibrosis-induced right-sided bronchopneumonia, gentamicin-induced acute tubular renal damage occurred, requiring dialysis. The patient died soon after of myocardial electro-mechanical dissociation. At necropsy there was, in addition to the idiopathic hypertrophic subvalvular cardiomyopathy, extensive bilateral pulmonary fibrosis, lamellar bodies in foam-cell intraalveolar macrophages, in hepatocytes and in the epithelium of the proximal and distal tubules. Although amiodarone had been discontinued three months previously, high concentrations of the drug were still present, especially in both lungs, fat tissue and the liver. |
| Authors | W Esinger, T Schleiffer, H Leinberger, F Hertrich, G Köhler, C Gröger, U Raute-Kreinsen
(Affiliation: Pathologisches Institut, Stadt Ludwigshafen am Rhein, St.-Elisabeth-Klinik, Saarlouis.)
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| Journal | Deutsche medizinische Wochenschrift (1946)
(Dtsch Med Wochenschr)
Vol. 113
Issue 42
Pg. 1638-41
(Oct 21 1988)
ISSN: 0012-0472 GERMANY, WEST |
| Vernacular Title | Steroidrefraktäre Lungenfibrose durch Amiodaron. Klinik und Morphologie nach einem amiodaronfreien Intervall von 3 Monaten. |
| PMID | 3181014
(Publication Type: Case Reports, English Abstract, Journal Article)
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| Chemical References |
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| Topics |
- Adipose Tissue
(metabolism)
- Amiodarone
(administration & dosage, adverse effects, pharmacokinetics)
- Cortisone
(therapeutic use)
- Drug Resistance
- Female
- Humans
- Liver
(metabolism)
- Lung
(metabolism)
- Middle Aged
- Pulmonary Fibrosis
(chemically induced, drug therapy, pathology)
- Time Factors
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