Carcinogenicity studies of masheri, a pyrolysed product of tobacco.

Abstract

The carcinogenicity of two commonly used brown and black varieties of masheri, a pyrolysed tobacco product, was studied by feeding the masheri through the diet at a 10% level to three different animal species of both sexes. In Sprague-Dawley rats, only brown masheri was used, while in Swiss mice and Syrian golden hamsters both varieties were used. In all the three species, forestomach papillomas were induced as a result of masheri treatment. In rats, 37% of animals showed forestomach papillomas while in mice and hamsters the incidence was 42-47% and 25-43%, respectively. No malignant changes were observed in any of the groups except 2/23 male hamsters showed forestomach carcinoma in the black masheri diet group.

• Authors: J R Kulkarni, V S Lalitha, S V Bhide
• Journal: Carcinogenesis (Carcinogenesis) Vol. 9 Issue 11 Pg. 2137-8 (Nov 1988) ISSN: 0143-3334 [Print] England
• PMID: 3180350 (Publication Type: Journal Article)

Chemical References

• Carcinogens
• Dentifrices
• Plant Extracts
• masheri

Topics

• Adenoma (chemically induced)
• Animals
• Carcinogens
• Cricetinae
• Dentifrices
• Lung Neoplasms (chemically induced)
• Mice
• Neoplasms, Experimental (chemically induced)
• Papilloma (chemically induced)
• Plant Extracts (toxicity)
• Plants, Toxic
• Stomach Neoplasms (chemically induced)
• Tobacco