Single-dose prophylaxis with cefotetan in elective abdominal surgery. A controlled trial.

Abstract

Single dose cefotetan was compared with either a combination of metronidazole and cefazolin given for 24 hours or 3 doses of cefuroxime as prophylaxis in elective abdominal surgery. Wound infections and infections at remote sites (UTI and RTI) were similar in all groups. In a third group prophylaxis of abdominal surgery using a single 2g dose of cefotetan was compared to 2 doses of the same drug, given 12 hours apart. There was no demonstrable advantage to giving 2 doses. The low incidence of post-operative infections seen in all groups indicates the efficacy of cefotetan in the surgical prophylaxis of elective abdominal surgery.

• Authors: J A Gruwez, J Lerut, M R Christiaens, J De Roose, L Vernimmen, J Hendrickx, F Trimpeneers, H Schroé, M Deruyter, K J Williams
• Journal: Chemioterapia : international journal of the Mediterranean Society of Chemotherapy (Chemioterapia) Vol. 7 Issue 4 Pg. 218-22 (Aug 1988) ISSN: 0392-906X [Print] Italy
• PMID: 3180299 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Metronidazole
• Cefotetan
• Cefazolin
• Cefuroxime

Topics

• Abdomen (surgery)
• Cefazolin (administration & dosage)
• Cefotetan (administration & dosage)
• Cefuroxime (therapeutic use)
• Colon (surgery)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Drug Therapy, Combination (therapeutic use)
• Humans
• Metronidazole (administration & dosage)
• Premedication
• Rectum (surgery)
• Surgical Wound Infection (prevention & control)