Dexfenfluramine and body weight regulation: experimental study with hoarding behavior.

Abstract

At very low doses dexfenfluramine, a serotonin agonist, is a potent inhibitor of hoarding behavior. The dose able to suppress 40% of this food motivated response (ED 40) is approximately 0.3 mg/kg. The action of dexfenfluramine is mediated through serotoninergic receptors because it is suppressed by a pretreatment with metergoline, a selective serotonin-receptor blocker, but is not modified by haloperidol, a dopamine antagonist.

• Authors: M Fantino, H Boucher, F Faïon, P Mathiot
• Journal: Clinical neuropharmacology (Clin Neuropharmacol) Vol. 11 Suppl 1 Pg. S97-104 ( 1988) ISSN: 0362-5664 [Print] United States
• PMID: 3180113 (Publication Type: Journal Article)

Chemical References

• Receptors, Serotonin
• Fenfluramine

Topics

• Animals
• Behavior, Animal (drug effects)
• Body Weight (drug effects)
• Eating (drug effects)
• Fenfluramine (pharmacology)
• Rats
• Receptors, Serotonin (drug effects)