Abstract | BACKGROUND: AIM: To investigate the impact of NAFLD-related comorbidities on safety and efficacy of RE for HCC treatment in a retrospective monocentric cohort study. PATIENTS AND METHODS: Safety and efficacy of RE were evaluated in patients with NAFLD-associated HCC. Hepatitis B virus (HBV)-related HCC patients served as controls, exhibiting matching Barcelona Liver Cancer Clinic (BCLC) stages while showing significantly fewer metabolic comorbidities. RESULTS: Overall, 87 HCC patients with NAFLD (mean age 71.3 ± 6.9 years) and 62 HCC patients with HBV (mean age 58.8 ± 10.9 years) not amenable to surgical or conventional locoregional treatments were included. Patients with HBV-related HCC had a comparable liver function to HCC patients with NAFLD. RE treatment-related toxicity did not differ between the two groups (increase in bilirubin Common Terminology Criteria for Adverse Events grade in 29 [38.7%] NAFLD and 20 [39.2%] HBV patients, p = 0.91). Overall survival was similar in HCC patients with NAFLD and HBV (11.1 [interquartile range, IQR, 18.27] vs. 9.3 months [IQR 14.73], p = 0.38), also in the subgroup analyses of BCLC B and C stages. CONCLUSION: RE showed similar survival outcomes at a comparable toxicity profile in HCC patients with NAFLD and HBV. NAFLD-associated metabolic comorbidities did not exhibit limitations for RE while offering comparable therapeutic efficacy as compared to HBV patients.
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Authors | Clemens Schotten, Lars P Bechmann, Paul Manka, Jens Theysohn, Alexander Dechêne, Amr El Fouly, Francesco Barbato, Ursula Neumann, Sonia Radünz, Svenja Sydor, Dominik Heider, Marino Venerito, Ali Canbay, Guido Gerken, Ken Herrmann, Heiner Wedemeyer, Jan Best |
Journal | Liver cancer
(Liver Cancer)
Vol. 8
Issue 6
Pg. 491-504
(Nov 2019)
ISSN: 2235-1795 [Print] Switzerland |
PMID | 31799206
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 by S. Karger AG, Basel. |