TXNIP induced by MondoA, rather than ChREBP, suppresses cervical cancer cell proliferation, migration and invasion.

Abstract

Evidence has indicated the associations between thioredoxin-interacting protein (TXNIP) and cancers. However, the role of TXNIP in cervical cancer remains unclear. Hence, this study aims to investigate the role of TXNIP in regulating cervical cancer cell proliferation, migration and invasion. TXNIP expression can be regulated by either MondoA or ChREBP in a cell- or tissue- dependent manner. Thus, we also explored whether TXNIP expression in cervical cancer can be regulated by MondoA or ChREBP. Our results showed that TXNIP expression was decreased in cervical cancer cells (HeLa, SiHa, CaSki, MS751, C-33A). Furthermore, TXNIP overexpression inhibited cell proliferation, migration and invasion in HeLa cells, whereas TXNIP silencing exerted the opposite effect in C-33A cells. Moreover, TXNIP expression could be induced by MondoA, rather than ChREBP in HeLa cells. Additionally, MondoA overexpression inhibited cell proliferation, migration and invasion through upregulating TXNIP in HeLa cells. In summary, TXNIP induced by MondoA, rather than ChREBP, suppresses cervical cancer cell proliferation, migration and invasion. Our findings provide new ideas for the prevention and treatment of cervical cancer.

• Authors: Junhua Zhang, Xingbo Tian, Huifang Yin, Songshu Xiao, Shuijing Yi, Youzhong Zhang, Fei Zeng
• Journal: Journal of biochemistry (J Biochem) Vol. 167 Issue 4 Pg. 371-377 (Apr 01 2020) ISSN: 1756-2651 [Electronic] England
• PMID: 31782782 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2019. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.

Chemical References

• Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
• Carrier Proteins
• MLXIP protein, human
• MLXIPL protein, human
• TXNIP protein, human

Topics

• Basic Helix-Loop-Helix Leucine Zipper Transcription Factors (metabolism)
• Carrier Proteins (genetics, metabolism)
• Cell Movement
• Cell Proliferation
• Cell Survival
• Female
• HeLa Cells
• Humans
• Uterine Cervical Neoplasms (metabolism, pathology)