Leukoencephalopathy after prophylactic radiation for leukaemia in ataxia telangiectasia.

Abstract

Children with ataxia telangiectasia have a high probability of developing acute lymphoblastic leukaemia, and have increased sensitivity to chemotherapy and irradiation. We report a 51/2 year old boy who had undiagnosed ataxia telangiectasia when he presented with acute lymphoblastic leukaemia. He subsequently developed a chemoradiation induced leukoencephalopathy after conventional central nervous system prophylaxis.

• Authors: J A Eyre, D Gardner-Medwin, G P Summerfield
• Journal: Archives of disease in childhood (Arch Dis Child) Vol. 63 Issue 9 Pg. 1079-80 (Sep 1988) ISSN: 1468-2044 [Electronic] England
• PMID: 3178268 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Methotrexate

Topics

• Ataxia Telangiectasia (complications, diagnosis)
• Brain (radiation effects)
• Brain Diseases (etiology)
• Brain Neoplasms (prevention & control)
• Child, Preschool
• Humans
• Male
• Methotrexate (adverse effects, therapeutic use)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (radiotherapy, therapy)
• Radiotherapy (adverse effects)