Abstract | PURPOSE: The renal excretion of uric acid is usually diminished in primary gout with respect to increased serum urate levels. To determine whether the renal excretion of uric acid precursors, hypoxanthine and xanthine, is also abnormal in primary gout, the concentrations of these purines were measured in plasma and 24-hour urine samples in normal subjects, in patients with primary gout and uric acid underexcretion, and in patients with enzyme deficiencies that are known to result in over-production of uric acid. SUBJECTS AND METHODS: RESULTS: Plasma hypoxanthine and xanthine were increased in the two groups of patients compared with the control subjects. Urinary hypoxanthine and xanthine levels were reduced in gouty patients compared with control subjects, whereas levels were increased in patients with uric acid overproduction. A positive correlation was found between the renal clearances of uric acid, hypoxanthine, and xanthine. CONCLUSION: The results indicate that the renal excretion of hypoxanthine and xanthine is severely impaired in most patients with primary gout.
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Authors | J G Puig, F A Mateos, M L Jiménez, T H Ramos |
Journal | The American journal of medicine
(Am J Med)
Vol. 85
Issue 4
Pg. 533-7
(Oct 1988)
ISSN: 0002-9343 [Print] United States |
PMID | 3177401
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hypoxanthines
- Xanthines
- Xanthine
- Uric Acid
- Hypoxanthine
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Topics |
- Adult
- Aged
- Female
- Gout
(blood, physiopathology, urine)
- Humans
- Hypoxanthine
- Hypoxanthines
(blood, urine)
- Kidney
(physiopathology)
- Male
- Middle Aged
- Uric Acid
(blood, urine)
- Xanthine
- Xanthines
(blood, urine)
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