[Effect of a new antiviral compound 1-morpholinomethyltetrahydro-2(1H)-pyrimidinone on the interaction of influenza virus proteins with flat lipid membranes].
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| Abstract |
The antiviral preparation 1-morpholinomethyltetrahydro-2(1H)-pyrimidinone (abbreviation DD-13) inhibiting reproduction of certain enveloped viruses belonging to groups of orthomyxoviruses and alphaviruses, influenza type A viruses among them, inhibited adsorption and insertion of influenza virus M protein into model bilayer lipid membranes. The preparation did not interact directly with lipid bilayers but, after pretreatment of M protein with it, inhibited M protein interaction with the membranes: adsorption and insertion into the bilayer DD-13 did not affect the interaction of influenza virus surface glycoproteins with the model lipid membranes. It is concluded that the DD-13 preparation, not interacting with the membranes directly, in native systems may modify the protein-lipid interactions at the stages of virus penetration into the cell, penetration of M protein-coated nucleocapsid into the cell nucleus through the nuclear membrane, as well as at the stage of virus particle assembly on the plasma membrane of the infected cell.
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| Authors | V A Tverdislov, I G Kharitonenkov, S V Sukhanov, A S Galabov |
| Journal | Voprosy virusologii (Vopr Virusol) 1988 May-Jun Vol. 33 Issue 3 Pg. 278-81 ISSN: 0507-4088 [Print] Russia (Federation) |
| Vernacular Title | O vliianii novogo protivovurusnogo soedineniia 1-morfolinometiltetragidro-2(1H)-pirimidinona na vzaimodeĭstvie belkov virusa grippa s ploskimi lipidnymi membranami. |
| PMID | 3176426 (Publication Type: Journal Article) |
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