Abstract |
The effects of three benzimidazole anthelmintics in dogs infected with a human strain of Strongyloides stercoralis were investigated. Cambendazole, but not thiabendazole or mebendazole, abrogated the subsequent development of a patent infection when administered at the same time as infection to immunocompetent dogs. None of the drugs eradicated infection when given after the onset of patency in immunosuppressed animals, although worm burdens were greatly reduced in dogs treated with cambendazole. The implications of these findings for the treatment of patients with strongyloidiasis, particularly those with disseminated infections, are discussed.
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Authors | D I Grove, C Northern |
Journal | Transactions of the Royal Society of Tropical Medicine and Hygiene
(Trans R Soc Trop Med Hyg)
Vol. 82
Issue 1
Pg. 146-9
( 1988)
ISSN: 0035-9203 [Print] England |
PMID | 3176142
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzimidazoles
- Cambendazole
- Mebendazole
- Thiabendazole
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Topics |
- Animals
- Benzimidazoles
(therapeutic use)
- Cambendazole
(therapeutic use)
- Dogs
- Feces
(parasitology)
- Immunosuppression Therapy
- Male
- Mebendazole
(therapeutic use)
- Parasite Egg Count
- Strongyloidiasis
(drug therapy, immunology, parasitology)
- Thiabendazole
(therapeutic use)
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