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Comparative acute systemic toxicity of sodium arsenite and dichloro(2-chlorovinyl)arsine in rabbits.

Abstract
The acute intravenous toxicity of sodium arsenite and dichloro(2-chlorovinyl)arsine (lewisite) has been compared in rabbits to provide a quantitative and qualitative model for future assessment of treatments of lewisite poisoning. The LD50 of sodium arsenite was 7.6 mg.kg-1; that for lewisite was 1.8 mg.kg-1. On the basis of arsenic content the former was 6.5 times less toxic than the latter. Significant differences in tissue arsenic content and pathology were found between the 2 materials. Histologically, changes were observed in the lungs and gall bladder after lewisite injection but not after sodium arsenite. It was concluded that use of sodium arsenite is not a suitable substitute model for lewisite poisoning.
AuthorsR H Inns, J E Bright, T C Marrs
JournalToxicology (Toxicology) Vol. 51 Issue 2-3 Pg. 213-22 (Oct 1988) ISSN: 0300-483X [Print] Ireland
PMID3176029 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Arsenicals
  • Arsenites
  • Sodium Compounds
  • lewisite
  • sodium arsenite
  • Arsenic
Topics
  • Animals
  • Arsenic (metabolism, toxicity)
  • Arsenic Poisoning
  • Arsenicals (metabolism)
  • Arsenites
  • Biliary Tract (drug effects, pathology)
  • Lethal Dose 50
  • Liver (drug effects, pathology)
  • Lung (drug effects, pathology)
  • Rabbits
  • Sodium Compounds
  • Tissue Distribution

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