General pharmacological actions of
M73101, a new non-steroidal
analgesic anti-inflammatory
drug were investigated in mice, rats, guinea pigs, rabbits, cats and dogs.
Intravenous administration of
M73101 produced a slight transient fall in blood pressure, an increase in heart rate and a respiratory stimulation, but no remarkable change in the electrocardiogram. The contraction induced by
epinephrine in the isolated ear vessels of rabbits relaxed by
M73101. In the isolated trachea of guinea pigs,
M73101 relaxed the contraction induced by
histamine. Furthermore,
M73101 inhibited the bronchoconstriction by
histamine but not by
bradykinin in guinea pigs. These properties of
M73101 on the tracheal smooth muscle were similar to those seen with
aminopyrine but different from those seen with
aspirin which inhibited only the contraction by
bradykinin in vivo, suggesting that
M73101 is a compound with properties similar to basic non-steroidal anti-inflammatory drugs.
M73101 inhibited the intestinal propulsion in mice and also the gastrointestinal movement in rats and dogs. Moreover,
M73101 showed a
spasmolytic activity on the isolated ileum of guinea pigs, but such was not due to any specific antagonistic action on the chemical mediators. On the other hand,
M73101 had no effect on the isolated uterus and vas deferens of rats.
M73101, unlike
aminopyrine and
phenylbutazone, slightly increased urine volume and
electrolytes excretion in rats, indicating that this compound probably does not produced
edema.
M73101 showed no significant pharmacological activities on the
blood sugar level, blood coagulation, platelet aggregation,
methemoglobin formation and local irritation.