Higher Cholesterol Level Predicts Cardiovascular Event and Inversely Associates With Mortality in Hemodialysis Patients: 10-Year Outcomes of the Q-Cohort Study.

Abstract	The prevalence of atherosclerotic diseases is higher in hemodialysis patients. The aim of the current study was to investigate associations between cholesterol level and the incidences of cardiovascular disease (CVD) and mortality in hemodialysis patients. A total of 3517 participants undergoing maintenance hemodialysis were followed up for 10 years. Total cholesterol (TC) level was divided into quartile in baseline data. The multivariate analyses were calculated by a Cox proportional hazards model. The incidences of ischemic heart disease (IHD), peripheral artery disease (PAD), and CVD were significantly positively associated with higher cholesterol levels after adjustment for confounding factors (P < 0.01, P = 0.04, and P < 0.01, respectively). Furthermore, the incidences of cancer-associated mortality and all-cause mortality were significantly positively associated with lower cholesterol levels after adjustment for confounding factors (both P < 0.01). The lowest TC level at all-cause mortality risk was 179 mg/dL. From these results, higher TC predicts IHD, PAD, and CVD events, and lower TC predicts cancer-associated mortality and all-cause mortality in patients undergoing maintenance hemodialysis.
Authors	Toshiaki Nakano, Hiroto Hiyamuta, Ryusuke Yotsueda, Shigeru Tanaka, Masatomo Taniguchi, Kazuhiko Tsuruya, Takanari Kitazono
Journal	Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy (Ther Apher Dial) Vol. 24 Issue 4 Pg. 431-438 (Aug 2020) ISSN: 1744-9987 [Electronic] Australia
PMID	31702859 (Publication Type: Journal Article, Multicenter Study, Observational Study)
Copyright	© 2019 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy.
Chemical References	Cholesterol
Topics	Aged Cardiovascular Diseases (blood, epidemiology) Cholesterol (blood) Cohort Studies Comorbidity Female Humans Hyperlipidemias (blood, epidemiology) Incidence Japan (epidemiology) Kidney Failure, Chronic (blood, epidemiology) Longitudinal Studies Male Middle Aged Renal Dialysis (methods, mortality) Risk Factors

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