Effects of enfenamic acid and its zinc salt on wound-healing.

Abstract

Dose-matched comparison between zinc-salt of enfenamic acid and the parent compound was carried out in experimentally wounded male albino rats bearing either sutured incision, dead-space or excision wounds. Result showed that enfenamic-acid significantly decreased breaking-strength of incision wounds and this effects was totally reversed by zinc present in enfenamic acid-zinc salt. Both the parent compound and the salt had significant granulation suppressant effect in dead-space wounds. In excision wounds epithelization was enhanced by enfenamic acid only. The wound contraction was not affected by either test compound.

• Authors: C M Rao, A Kumar, D R Kulkarni
• Journal: Indian journal of physiology and pharmacology (Indian J Physiol Pharmacol) 1988 Jan-Mar Vol. 32 Issue 1 Pg. 61-6 ISSN: 0019-5499 [Print] India
• PMID: 3169962 (Publication Type: Journal Article)

Chemical References

• ortho-Aminobenzoates
• enfenamic acid
• Zinc

Topics

• Analysis of Variance
• Animals
• Dose-Response Relationship, Drug
• Male
• Rats
• Wound Healing (drug effects)
• Zinc
• ortho-Aminobenzoates (pharmacology)