A new antimicrobial indoloditerpene from a marine-sourced fungus aspergillus versicolor ZZ761.

Abstract

A new indoloditerpene (1) and fifteen known compounds (2-16) were isolated from a marine-derived fungus Aspergillus versicolor ZZ761. Structure of the new compound was elucidated as (3 R,9S,12R,13S,17S,18S)-2-carbonyl-3-hydroxylemeniveol based on its HRESIMS data, NMR spectroscopic analyses, the Mosher's method, and ECD calculation. This new indoloditerpene (1) showed antimicrobial activities with MIC values of 20.6 μM against Escherichia coli and 22.8 μM against Candida albicans. Diorcinol (2) and versicolorin B (6) had activities in inhibiting the proliferation of human glioma U87MG and U251 cells with IC50 values of 4.4 and 6.2 μM and 11.3 and 30.5 μM, respectively.

• Authors: Di Zhang, Wenwen Yi, Hengju Ge, Zhizhen Zhang, Bin Wu
• Journal: Natural product research (Nat Prod Res) Vol. 35 Issue 18 Pg. 3114-3119 (Sep 2021) ISSN: 1478-6427 [Electronic] England
• PMID: 31686531 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents
• Diterpenes
• Phytochemicals

Topics

• Anti-Infective Agents (isolation & purification, pharmacology)
• Aquatic Organisms
• Aspergillus (chemistry)
• Candida albicans
• Cell Line, Tumor
• Diterpenes (isolation & purification, pharmacology)
• Humans
• Phytochemicals (isolation & purification, pharmacology)