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The efficacy of 5-fluorouracil in human colorectal cancer is not enhanced by thymidylate synthetase inhibition with CB3717 (N10-propargyl-5,8 dideazafolic acid).

AuthorsB M Cantwell, A L Harris
JournalBritish journal of cancer (Br J Cancer) Vol. 58 Issue 2 Pg. 189-90 (Aug 1988) ISSN: 0007-0920 [Print] England
PMID3166908 (Publication Type: Journal Article)
Chemical References
  • Quinazolines
  • CB 3717
  • Folic Acid
  • Thymidylate Synthase
  • Fluorouracil
Topics
  • Adenocarcinoma (drug therapy)
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Colonic Neoplasms (drug therapy)
  • Fluorouracil (therapeutic use)
  • Folic Acid (analogs & derivatives, therapeutic use)
  • Humans
  • Middle Aged
  • Quinazolines (therapeutic use)
  • Rectal Neoplasms (drug therapy)
  • Thymidylate Synthase (antagonists & inhibitors)

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