Long non-coding RNA (
lncRNA), a member of
non-coding RNA family with over 200
nucleotides in length, typically serves as an oncogene or
tumor suppressor in
tumor progression, such as
cancer cell proliferation, apoptosis and glycolysis. Recent studies manifested
lncRNA LINC00857 was involved in cell cycle regulation of
lung cancer. Due to complicated networks in
tumorigenesis, the potential roles of LINC00857 underlying
lung cancer progression still need further investigation. In this study, we explored the expression of LINC00857 in
lung adenocarcinoma (LUAD) tissues and LUAD cell lines and found a dramatical upregulation of LINC00857 compared with the adjacent normal lung tissues and BEAS-2B cell line, respectively. Then, LINC00857 knockdown led to the cell proliferation and glycolysis was repressed, while the apoptosis was elevated in LUAD cell lines. Furthermore, we identified a direct interaction between LINC00857 and miR-1179 in LUAD cells using bioinformatic method and report assay. Finally, we evidenced LINC00857 promoted cell growth and glycolysis and repressed apoptosis via sponging miR-1179 and further regulating sperm-associated
antigen 5 (SPAG5) expression in LUAD cell lines. Hence, our results authenticated that
lncRNA LINC00857 regulated the cell proliferation, glycolysis and apoptosis of LUAD cells mainly through targeting the miR-1179/SPAG5 axis, which might be a novel insight into
lung cancer progression and provided a potential target for clinical treatment of LUAD patients.