Efficacy of a skin care cream with TRPV1 inhibitor 4-t-butylcyclohexanol in the topical therapy of perioral dermatitis.

Abstract

BACKGROUND:

Perioral dermatitis is a clinically distinctive reaction pattern of facial dermatitis, including redness, dryness, burning, pruritus and skin tightness. A gold standard treatment remains unclear.

OBJECTIVES:

Our study evaluates the clinical value of a skin care cream with the transient receptor potential vanilloid type 1 inhibitor 4-t-butylcyclohexanol in POD patients over 8 weeks.

METHODS:

This open, unblinded 8-week clinical trial included 48 patients. A skin care cream containing 4-t-butylcyclohexanol was applied over a period of 8 weeks. Standardized questionnaires were used at baseline, 4 and 8 weeks, for history documentation, objective and subjective severity scores, and quality of life assessments. Six different skin physiology parameters were assessed at all timepoints.

RESULTS:

The perioral dermatitis severity score decreased significantly during the treatment period. This was mirrored by significantly lower patients' subjective numerical rating score and an improved quality of life score. Transepidermal water loss, stratum corneum hydration and skin erythema improved significantly during the treatment period.

CONCLUSION:

This transient receptor potential vanilloid type 1 inhibitor-based skin care cream improved subjective and objective parameters of perioral dermatitis. Decreased transepidermal water loss values and increased stratum corneum hydration demonstrate a restored skin barrier function. Consequently, the topical inhibition of these receptors is a promising management option for POD.

• Authors: Jerome Srour, Julia Bengel, Teresa Linden, Zorica Jovanovic, Dennis Roggenkamp, Markus Reinholz, Christoph Rothenberger, Gitta Neufang, Andreas Wollenberg
• Journal: Journal of cosmetic dermatology (J Cosmet Dermatol) Vol. 19 Issue 6 Pg. 1409-1414 (Jun 2020) ISSN: 1473-2165 [Electronic] England
• PMID: 31660683 (Publication Type: Clinical Trial, Journal Article)
• Copyright: © 2019 The Authors. Journal of Cosmetic Dermatology Published by Wiley Periodicals, Inc.

Chemical References

• Cyclohexanols
• TRPV Cation Channels
• TRPV1 protein, human
• 4-tert-butylcyclohexanol

Topics

• Adult
• Aged
• Aged, 80 and over
• Cyclohexanols (pharmacology, therapeutic use)
• Dermatitis, Perioral (diagnosis, drug therapy)
• Female
• Humans
• Male
• Middle Aged
• Quality of Life
• Severity of Illness Index
• Skin Cream (pharmacology, therapeutic use)
• TRPV Cation Channels (antagonists & inhibitors)
• Treatment Outcome
• Water Loss, Insensible (drug effects)
• Young Adult