Abstract |
13-cis-Retinoic acid, a drug used at high doses in the treatment of recalcitrant acne, increased the permeability of rat-liver microsomal membranes to mannose 6-phosphate in vitro, as indicated by an increase in mannose-6-phosphatase activity. At the same concentrations, four other amphiphiles, including all-trans-retinoic acid, were much less effective. 13-cis-Retinoic acid also inhibited retinol esterification and benzo[a]pyrene hydroxylation in microsome preparations in vitro. Although the molecular mechanism and the reversibility of these effects have not yet been studied, the interaction of 13-cis-retinoic acid with cell membranes may well be involved in both its therapeutic and toxic manifestations.
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Authors | M D Ball, J A Olson |
Journal | Biochimica et biophysica acta
(Biochim Biophys Acta)
Vol. 961
Issue 1
Pg. 139-43
(Jul 01 1988)
ISSN: 0006-3002 [Print] Netherlands |
PMID | 3164219
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Hexosephosphates
- Mannosephosphates
- Vitamin A
- Benzo(a)pyrene
- mannose-6-phosphate
- Tretinoin
- Isotretinoin
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Topics |
- Animals
- Benzo(a)pyrene
(metabolism)
- Female
- Hexosephosphates
(metabolism)
- Hydrolysis
- Hydroxylation
- Isomerism
- Isotretinoin
- Kinetics
- Mannosephosphates
(metabolism)
- Microsomes, Liver
(drug effects, metabolism)
- Rats
- Rats, Inbred F344
- Tretinoin
(pharmacology)
- Vitamin A
(metabolism)
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