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13-cis-retinoic acid stimulates in vitro mannose 6-phosphate hydrolysis and inhibits retinol esterification and benzo[a]pyrene hydroxylation by rat-liver microsomes.

Abstract
13-cis-Retinoic acid, a drug used at high doses in the treatment of recalcitrant acne, increased the permeability of rat-liver microsomal membranes to mannose 6-phosphate in vitro, as indicated by an increase in mannose-6-phosphatase activity. At the same concentrations, four other amphiphiles, including all-trans-retinoic acid, were much less effective. 13-cis-Retinoic acid also inhibited retinol esterification and benzo[a]pyrene hydroxylation in microsome preparations in vitro. Although the molecular mechanism and the reversibility of these effects have not yet been studied, the interaction of 13-cis-retinoic acid with cell membranes may well be involved in both its therapeutic and toxic manifestations.
AuthorsM D Ball, J A Olson
JournalBiochimica et biophysica acta (Biochim Biophys Acta) Vol. 961 Issue 1 Pg. 139-43 (Jul 01 1988) ISSN: 0006-3002 [Print] Netherlands
PMID3164219 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Hexosephosphates
  • Mannosephosphates
  • Vitamin A
  • Benzo(a)pyrene
  • mannose-6-phosphate
  • Tretinoin
  • Isotretinoin
Topics
  • Animals
  • Benzo(a)pyrene (metabolism)
  • Female
  • Hexosephosphates (metabolism)
  • Hydrolysis
  • Hydroxylation
  • Isomerism
  • Isotretinoin
  • Kinetics
  • Mannosephosphates (metabolism)
  • Microsomes, Liver (drug effects, metabolism)
  • Rats
  • Rats, Inbred F344
  • Tretinoin (pharmacology)
  • Vitamin A (metabolism)

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