Abstract | OBJECTIVE: METHODS: Data from the PubMed and Embase databases were retrieved for clinical research published between 1990 and 2018. The Newcastle-Ottawa Scale was used to evaluate the quality of the articles. A meta-analysis was performed using the RevMan 5.3 software provided by the Cochrane Collaboration Network. RESULTS: Seventeen articles were eligible for the meta-analysis. In these articles, over 35 risk factors for esophageal fistula formation were described and 17 risk factors were analyzed. Significant differences in the odds of developing an esophageal perforation were found with regard to age (OR 2.34, 95% CI 1.08-5.03, p = 0.001), ulcerative type (OR 2.72, 95% CI 1.43-5.16, p = 0.002), histology (OR 4.16, 95% CI 1.14-15.12, p = 0.03), T stage (OR 2.66, 95% CI 1.44-4.91, p = 0.002), short-term response (OR 2.21, 95% CI 1.06-4.62, p = 0.03), chemotherapy regimen (OR 2.80, 95% CI 1.38-5.68, p = 0.005), and stenosis (OR 2.00, 95% CI 1.03-3.89, p = 0.04). CONCLUSIONS:
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Authors | Chao Zhu, Songping Wang, Yunhong You, Keke Nie, Youxin Ji |
Journal | Oncology research and treatment
(Oncol Res Treat)
Vol. 43
Issue 1-2
Pg. 34-41
( 2020)
ISSN: 2296-5262 [Electronic] Switzerland |
PMID | 31639800
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | © 2019 S. Karger AG, Basel. |
Topics |
- Age Factors
- Chemoradiotherapy
(adverse effects, methods)
- Esophageal Fistula
(diagnosis, etiology, therapy)
- Esophageal Neoplasms
(complications, diagnosis, radiotherapy)
- Humans
- Neoplasm Staging
- Odds Ratio
- Radiotherapy
(adverse effects, methods)
- Risk Assessment
- Risk Factors
- Sex Factors
- Treatment Outcome
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