5q- syndrome terminating in acute myeloid leukemia. Karyotype evolution and immunologic characterization of blast cells.

Abstract

We report a case of 5q- syndrome that progressed to acute nonlymphocytic leukemia after 9 years of clinically and morphologically stable disease. The transition from the chronic to the leukemic phase was characterized by the appearance of an additional cytogenetic anomaly [inv(2)] in the cell carrying the 5q-, together with the expansion of a clone showing an apparently normal karyotype.

• Authors: E Donti, A Tabilio, G V Donti, C Mecucci, A Carotti, F Grignani, M F Martelli
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 32 Issue 2 Pg. 205-9 (Jun 1988) ISSN: 0165-4608 [Print] United States
• PMID: 3163260 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal

Topics

• Anemia, Refractory (complications, genetics, pathology)
• Antibodies, Monoclonal
• Blast Crisis (genetics, immunology, pathology)
• Chromosome Deletion
• Chromosomes, Human, Pair 5
• Humans
• Karyotyping
• Leukemia, Myeloid, Acute (etiology, genetics, pathology)
• Male
• Middle Aged
• Syndrome