Evaluation of the Impact of Sarcopenia in Patients with Acute Mesenteric Ischemia.

Abstract

BACKGROUND:

Sarcopenia has been identified as a prognostic factor in several diseases. The aim of this study was to investigate the impact of sarcopenia in patients with acute mesenteric ischemia.

METHODS:

Consecutive patients admitted for acute mesenteric ischemia were retrospectively included at the University Hospital of Nice. Sarcopenia was assessed by the measurement of total psoas area normalized for height (TPA/H) on CT-scan and was defined as a TPA/H inferior to the lowest sex-specific quartile. The management of the patients and the 30-day outcomes were compared between sarcopenic and nonsarcopenic patients. Correlations between the TPA/H and biological characteristics were investigated.

RESULTS:

Among the 80 patients included, the lowest quartile of TPA/H that defined sarcopenia was 406.1 mm2/m2 for men and 307 mm2/m2 for women. The rate of revascularization or the need of intestinal resection did not significantly differ between sarcopenic and nonsarcopenic patients (10.5% vs. 26.2%, P = 0.214 and 26.3% vs. 47.5%, P = 0.118 respectively). The 30-day mortality did not significantly differ between the two groups (63.2% vs. 47.5%, P = 0.297). The TPA/H was significantly negatively correlated with the neutrophil, thrombocyte, and monocyte counts (r = -0.283; -0.288, -0.225, P < 0.05) and positively correlated with the hemoglobin concentration and the glomerular filtration rate (r = 0.368; 0.261, P < 0.05).

CONCLUSIONS:

Further studies on longer follow-up period would be of interest to fully understand the prognostic value of sarcopenia in patients with acute mesenteric ischemia.

• Authors: Fabien Lareyre, Emmanuel Augène, Julien Chikande, Lucas Guidi, Ali Ballaith, Caroline Caradu, Réda Hassen-Khodja, Juliette Raffort
• Journal: Annals of vascular surgery (Ann Vasc Surg) Vol. 63 Pg. 170-178.e1 (Feb 2020) ISSN: 1615-5947 [Electronic] Netherlands
• PMID: 31629853 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Topics

• Acute Disease
• Aged
• Aged, 80 and over
• Female
• Humans
• Male
• Mesenteric Ischemia (complications, diagnostic imaging, mortality, surgery)
• Mesenteric Vascular Occlusion (complications, diagnostic imaging, mortality, surgery)
• Middle Aged
• Psoas Muscles (diagnostic imaging)
• Retrospective Studies
• Risk Factors
• Sarcopenia (complications, diagnostic imaging, mortality)
• Time Factors
• Treatment Outcome