The association between lipid profiles and the neurologic outcome in patients with out-of-hospital cardiac arrest.

Abstract

BACKGROUND:

Lipid profiles are known to be a risk factor for development of cardiovascular disease. However, the relationship between lipid profiles and outcome in out-of-hospital cardiac arrest (OHCA) survivors remains unclear. We aimed to examine the association between lipid profiles and neurologic outcome in OHCA survivors.

METHODS:

This retrospective observational study included adult (≥18 years) OHCA survivors between January 2016 and December 2018. We measured patients' lipid profiles after return of spontaneous circulation (ROSC) including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglyceride. The primary outcome was neurologic outcome at hospital discharge. Good neurologic outcome was defined cerebral performance categories 1 and 2.

RESULTS:

A total of 182 patients were included. Of them, 57 (31.3%) were discharged with good neurologic outcomes. Median serum levels of total cholesterol (178.0 vs. 123.0 mg/dL), HDL (44.0 vs. 31.0 mg/dL), and LDL (104.0 vs. 75.0 mg/dL) were significantly higher in patients with good neurologic outcome. The area under the curves of total cholesterol, HDL, LDL, and triglyceride were 0.742 (95% confidence interval [CI], 0.672-0.803), 0.729 (95% CI, 0.658-0.792), 0.683 (95% CI, 0.610-0.750), and 0.572 (95% CI, 0.497-0.645), respectively. Total cholesterol (odds ratio [OR], 1.013; 95% CI, 1.000-1.025; p = 0.043) and HDL (OR, 1.071; 95% CI, 1.021-1.123; p = 0.005) levels were associated with good neurologic outcomes.

CONCLUSIONS:

The levels of total cholesterol and HDL after ROSC were associated with good neurologic outcomes in patients with OHCA, without considering the effect of other lipid profiles simultaneously.

• Authors: Hyoung Youn Lee, Dong Hun Lee, Byung Kook Lee, Kyung Woon Jeung, Yong Hun Jung, Jung Soo Park, Jin Hong Min, Yong Il Min
• Journal: Resuscitation (Resuscitation) Vol. 145 Pg. 26-31 (12 2019) ISSN: 1873-1570 [Electronic] Ireland
• PMID: 31626864 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• Cholesterol, HDL
• Cholesterol, LDL
• Triglycerides

Topics

• Aged
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Female
• Humans
• Male
• Middle Aged
• Out-of-Hospital Cardiac Arrest (blood, therapy)
• Retrospective Studies
• Time Factors
• Triglycerides (blood)