Abstract | BACKGROUND: METHODS: We retrospectively collected data on adult patients with haematologic malignancies who received posaconazole prophylaxis during chemotherapy from April 2014 through May 2018. A total of 242 cases with PPCs, 88 in the oral suspension group and 154 in the tablet group, were included in this study. RESULTS: Patients receiving tablets achieved a significantly higher mean PPC than did those on oral suspension (1.631 ± 0.878 μg/mL in the tablet group vs. 0.879 ± 0.585 μg/mL in the oral suspension group). One hundred and thirty-seven of 154 patients (89.0%) receiving tablets had PPCs of 0.7 μg/mL or more, while only 41 of 88 patients (46.6%) receiving oral suspension attained an optimal level (P < .001). The incidence of breakthrough IFIs was significantly higher in the oral suspension group compared with in the tablet group (14.8% of oral suspension vs. 4.5% of tablet; P = .005). In the analysis including patients receiving posaconazole tablets, hypoalbuminemia (< 3.5 g/dL) was found to be a risk factor associated with suboptimal levels (odds ratio: 8.872; 95% confidence interval: 3.011 - 26.141; P < .001). CONCLUSIONS:
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Authors | Jihyu Oh, Cheol-In Kang, Si-Ho Kim, Kyungmin Huh, Sun Young Cho, Doo Ryeon Chung, Soo-Youn Lee, Chul Won Jung, Kyong Ran Peck |
Journal | Mycoses
(Mycoses)
Vol. 63
Issue 1
Pg. 89-94
(Jan 2020)
ISSN: 1439-0507 [Electronic] Germany |
PMID | 31610064
(Publication Type: Journal Article)
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Copyright | © 2019 Blackwell Verlag GmbH. |
Chemical References |
- Antifungal Agents
- Suspensions
- Tablets
- Triazoles
- posaconazole
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Topics |
- Administration, Oral
- Adult
- Antifungal Agents
(therapeutic use)
- Drug Monitoring
- Female
- Hematologic Neoplasms
(complications, microbiology)
- Humans
- Hypoalbuminemia
(blood)
- Invasive Fungal Infections
(drug therapy, prevention & control)
- Male
- Middle Aged
- Retrospective Studies
- Risk Factors
- Suspensions
(pharmacology)
- Tablets
(pharmacology)
- Treatment Outcome
- Triazoles
(administration & dosage, adverse effects, blood, therapeutic use)
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