Abstract | CONTEXT: OBJECTIVE: To evaluate the effect of the incretin hormones on endocrine pancreatic function in patients with ESRD. DESIGN AND SETTING: Twelve ESRD patients on chronic hemodialysis and 12 matched healthy controls, all with normal oral glucose tolerance test, were included. On 3 separate days, a 2-hour euglycemic clamp followed by a 2-hour hyperglycemic clamp (3 mM above fasting level) was performed with concomitant infusion of GLP-1 (1 pmol/kg/min), GIP (2 pmol/kg/min), or saline administered in a randomized, double-blinded fashion. A 30% lower infusion rate was used in the ESRD group to obtain comparable incretin hormone plasma levels. RESULTS: During clamps, comparable plasma glucose and intact incretin hormone concentrations were achieved. The effect of GLP-1 to increase insulin concentrations relative to placebo levels tended to be lower during euglycemia in ESRD and was significantly reduced during hyperglycemia (50 [8-72]%, P = 0.03). Similarly, the effect of GIP relative to placebo levels tended to be lower during euglycemia in ESRD and was significantly reduced during hyperglycemia (34 [13-50]%, P = 0.005). Glucagon was suppressed in both groups, with controls reaching lower concentrations than ESRD patients. CONCLUSIONS:
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Authors | Morten B Jørgensen, Thomas Idorn, Casper Rydahl, Henrik P Hansen, Iain Bressendorff, Lisbet Brandi, Nicolai J Wewer Albrechtsen, Gerrit van Hall, Bolette Hartmann, Jens J Holst, Filip K Knop, Mads Hornum, Bo Feldt-Rasmussen |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 105
Issue 1
(01 01 2020)
ISSN: 1945-7197 [Electronic] United States |
PMID | 31608934
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © Endocrine Society 2019. All rights reserved. For permissions, please e-mail: [email protected]. |
Chemical References |
- Incretins
- Insulin
- Glucagon-Like Peptide 1
- Glucagon
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Topics |
- Adult
- Denmark
- Double-Blind Method
- Female
- Glucagon
(blood)
- Glucagon-Like Peptide 1
(administration & dosage, pharmacology)
- Glucose Clamp Technique
- Glucose Tolerance Test
- Humans
- Incretins
(administration & dosage, pharmacology)
- Insulin
(metabolism)
- Insulin Secretion
(drug effects)
- Islets of Langerhans
(drug effects, pathology, physiology)
- Kidney Failure, Chronic
(metabolism, pathology, physiopathology, therapy)
- Male
- Middle Aged
- Renal Dialysis
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