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Effects of three histaminergic compounds on function and oxygen consumption of isolated guinea-pig hearts.

Abstract
First experiences in man indicate, that even in catecholamine-insensitive congestive cardiomyopathy a considerable improvement of myocardial function can be attained by the H2-receptor agonist impromidine. In an isolated, pressure-volume work performing guinea-pig heart preparation cardiac effects of three histaminergic compounds (Na,5-dimethylhistamine (HC1)2, 5-ethyl-Na-methyl-histamine (HC1)2, Na,Na-dimethyl-histamine (HC1)2) were examined. Influences on function and myocardial oxygen consumption were compared to those obtained by impromidine. Dose-response curves for the histamine derivatives were 1.7-2.5 orders of magnitude right of the impromidine curves. Maximal inotropic stimulation was greater for Na,5-dimethyl-histamine (HC1)2 than for impromidine. All compounds exhibited a high chronotropic effect and, at high concentrations, a net coronary dilating effect.
AuthorsB Permanetter, G Baumann, J Dörner, W Schunack, H Blömer
JournalAgents and actions (Agents Actions) Vol. 16 Issue 3-4 Pg. 215-8 (Apr 1985) ISSN: 0065-4299 [Print] Switzerland
PMID3160223 (Publication Type: Journal Article)
Chemical References
  • Imidazoles
  • Methylhistamines
  • Receptors, Histamine
  • Receptors, Histamine H2
  • Impromidine
Topics
  • Animals
  • Dose-Response Relationship, Drug
  • Guinea Pigs
  • Heart (drug effects)
  • Hemodynamics (drug effects)
  • Imidazoles (pharmacology)
  • Impromidine
  • In Vitro Techniques
  • Methylhistamines (pharmacology)
  • Myocardium (metabolism)
  • Oxygen Consumption (drug effects)
  • Receptors, Histamine (drug effects)
  • Receptors, Histamine H2 (drug effects)

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