Abstract |
First experiences in man indicate, that even in catecholamine-insensitive congestive cardiomyopathy a considerable improvement of myocardial function can be attained by the H2-receptor agonist impromidine. In an isolated, pressure-volume work performing guinea-pig heart preparation cardiac effects of three histaminergic compounds (Na,5-dimethylhistamine (HC1)2, 5-ethyl-Na-methyl-histamine (HC1)2, Na,Na-dimethyl-histamine (HC1)2) were examined. Influences on function and myocardial oxygen consumption were compared to those obtained by impromidine. Dose-response curves for the histamine derivatives were 1.7-2.5 orders of magnitude right of the impromidine curves. Maximal inotropic stimulation was greater for Na,5-dimethyl-histamine (HC1)2 than for impromidine. All compounds exhibited a high chronotropic effect and, at high concentrations, a net coronary dilating effect.
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Authors | B Permanetter, G Baumann, J Dörner, W Schunack, H Blömer |
Journal | Agents and actions
(Agents Actions)
Vol. 16
Issue 3-4
Pg. 215-8
(Apr 1985)
ISSN: 0065-4299 [Print] Switzerland |
PMID | 3160223
(Publication Type: Journal Article)
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Chemical References |
- Imidazoles
- Methylhistamines
- Receptors, Histamine
- Receptors, Histamine H2
- Impromidine
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Topics |
- Animals
- Dose-Response Relationship, Drug
- Guinea Pigs
- Heart
(drug effects)
- Hemodynamics
(drug effects)
- Imidazoles
(pharmacology)
- Impromidine
- In Vitro Techniques
- Methylhistamines
(pharmacology)
- Myocardium
(metabolism)
- Oxygen Consumption
(drug effects)
- Receptors, Histamine
(drug effects)
- Receptors, Histamine H2
(drug effects)
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