Abstract |
We studied the effects of a non- narcotic, centrally acting antitussive, fominoben (PB89), on hypoxia in sixty patients suffering from chronic obstructive lung diseases (COLD), utilizing a double-blind method and using the antitussive dextromethorphan as a reference drug. By the oral administration of a dose of 2 fominoben tablets (160 mg) three times a day for 2 weeks, a significant increase in arterial O2 pressure (PaO2), a decrease in arterial CO2 pressure (PaCO2), and a rise in pH were observed. However, alveolar-arterial O2 difference (A-aDO2) was not improved. On the other hand, after administration of a dose of 2 dextromethorphan tablets (30 mg) three times a day for 2 weeks, no increase in PaO2, no decrease in PaCo2 and no improvement in A-aDO2 were observed, although a rise in pH was seen. The increase in PaO2 by fominoben was marked in COLD with dyspnoea. No improvement of A-aDO2 despite a decrease in PaCO2 suggests that fominoben might increase alveolar ventilation, in spite of its effect as an antitussive, exerting a favourable effect on hypoxia. It is, therefore, speculated that the cough centre and the respiratory centre are capable of functioning independently of each other.
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Authors | T Sasaki, M Sugiyama, H Sasaki, S Suzuki, T Takishima |
Journal | The Journal of international medical research
(J Int Med Res)
Vol. 13
Issue 2
Pg. 96-101
( 1985)
ISSN: 0300-0605 [Print] England |
PMID | 3158563
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antitussive Agents
- Morpholines
- Levorphanol
- Dextromethorphan
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Topics |
- Aged
- Antitussive Agents
- Dextromethorphan
(administration & dosage, pharmacology, therapeutic use)
- Double-Blind Method
- Female
- Humans
- Hypoxia
(drug therapy, etiology)
- Levorphanol
(analogs & derivatives)
- Lung Diseases, Obstructive
(complications, drug therapy)
- Male
- Middle Aged
- Morpholines
(administration & dosage, pharmacology, therapeutic use)
- Partial Pressure
- Respiratory Center
(drug effects)
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