Bioactive Streptoglutarimides A-J from the Marine-Derived Streptomyces sp. ZZ741.

Abstract

The new streptoglutarimides A-J (1-10) and the known streptovitacin A (11) were isolated from a marine-derived actinomycete, Streptomyces sp. ZZ741. Structures of the isolated compounds were elucidated based on their HRESIMS data, extensive NMR spectroscopic analyses, ECD calculations, Mosher's method, and a single-crystal X-ray diffraction experiment. Streptoglutarimide H (8) and streptovitacin A (11) showed potent antiproliferative activity against human glioma U87MG and U251 cells with IC50 values of 1.5-3.8 μM for 8 and 0.05-0.22 μM for 11. All isolated compounds exhibited antimicrobial activity with MIC values of 9-11 μg/mL against methicillin-resistant Staphylococcus aureus, 8-12 μg/mL against Escherichia coli, and 8-20 μg/mL against Candida albicans.

• Authors: Di Zhang, Wenwen Yi, Hengju Ge, Zhizhen Zhang, Bin Wu
• Journal: Journal of natural products (J Nat Prod) Vol. 82 Issue 10 Pg. 2800-2808 (10 25 2019) ISSN: 1520-6025 [Electronic] United States
• PMID: 31584271 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents

Topics

• Anti-Infective Agents (chemistry, isolation & purification, pharmacology)
• Crystallography, X-Ray
• Magnetic Resonance Spectroscopy
• Methicillin-Resistant Staphylococcus aureus (drug effects)
• Streptomyces (chemistry)
• Water Microbiology