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Effect of diabetogenic action of streptozotocin on rat serum lipoproteins.

Abstract
After studying the diabetogenic action of streptozotocin in rats on adipose tissue cellularity, the authors attempted to demonstrate the influence of streptozotocin on cholesterol and phospholipid composition of the different serum lipoproteins. Intravenous injection of that antibiotic induced in rats a diabetes which appears at the latest on about the third day and finally remains at a fixed value at about the second week. All very low density lipoproteins (VLDL) are increased, which is not surprising since diabetes induces a hypertriglyceridemia and VLDL are triglyceride carriers. On the other hand, high density lipoproteins (HDL) are decreased, so that we can ask the question: Is HDL decrease due to diabetes or as a result of hypertriglyceridemia?
AuthorsC Brunet, M Luyckx, M Cazin
JournalMethods and findings in experimental and clinical pharmacology (Methods Find Exp Clin Pharmacol) Vol. 7 Issue 2 Pg. 87-91 (Feb 1985) ISSN: 0379-0355 [Print] Spain
PMID3157842 (Publication Type: Journal Article)
Chemical References
  • Blood Glucose
  • Cholesterol, HDL
  • Lipids
  • Lipoproteins
  • Phospholipids
  • Triglycerides
  • Streptozocin
  • Cholesterol
Topics
  • Animals
  • Blood Glucose (analysis)
  • Cholesterol (blood)
  • Cholesterol, HDL (blood)
  • Lipids (blood)
  • Lipoproteins (blood)
  • Male
  • Phospholipids (blood)
  • Rats
  • Rats, Inbred Strains
  • Streptozocin (pharmacology)
  • Triglycerides (blood)

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