Erythema multiforme after use of topical sulfacetamide.

Abstract

An 8-year-old boy developed erythema multiforme major after topical administration of sodium sulfacetamide for conjunctivitis. He had received systemic treatment with trimethoprim-sulfamethoxazole four months previously without evidence of drug allergy. There was no history of recent exposure to other drugs or evidence of herpes simplex or Mycoplasma infection. After 12 days of treatment with erythromycin ointment, 1% prednisolone eyedrops, systemic prednisone, and intravenous nafcillin, the patient's condition improved dramatically. A slit-lamp examination showed only superficial punctate keratitis. Two months later his visual acuity had improved from 20/200 bilaterally to R.E.: 20/40 and L.E.: 20/30.

• Authors: G I Genvert, E J Cohen, E D Donnenfeld, M H Blecher
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 99 Issue 4 Pg. 465-8 (Apr 15 1985) ISSN: 0002-9394 [Print] United States
• PMID: 3157322 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ophthalmic Solutions
• Sulfacetamide
• Nafcillin
• Erythromycin
• Prednisolone
• Prednisone

Topics

• Child
• Conjunctivitis (drug therapy)
• Drug Eruptions (drug therapy, etiology)
• Drug Hypersensitivity (drug therapy, etiology)
• Erythromycin (therapeutic use)
• Humans
• Male
• Nafcillin (therapeutic use)
• Ophthalmic Solutions
• Prednisolone (therapeutic use)
• Prednisone (therapeutic use)
• Stevens-Johnson Syndrome (chemically induced, drug therapy)
• Sulfacetamide (administration & dosage, adverse effects)