Abstract | BACKGROUND: Excessive expression of EGFR is closely related to tumor formation, transfer and deterioration, which has attracted much attention. EGFR overexpression may be detected in up to 90% of pancreatic tumors. However, drug resistance of EGFR inhibitors targeting treatment severely limits its clinical application. METHODS: In this study, Western blotting was used to detect the expression of p-Stat3, EGFR, Bcl-2, cleaved-caspase3 and Bax. Cell apoptosis was evaluated via flow cytometry. The colon assay and MTT assay were applied for detecting the cell proliferation in vitro. The xenograft mouse model was used to examine the cell proliferation in vivo. RESULTS: CONCLUSION: These results indicate that the combination of emodin with EGFR inhibitor is an effective therapeutic strategy to sensitize human pancreatic cancer.
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Authors | Zhaohong Wang, Hui Chen, Jingjing Chen, Zhong Hong, Yi Liao, Qiyu Zhang, Hongfei Tong |
Journal | Cancer management and research
(Cancer Manag Res)
Vol. 11
Pg. 8463-8473
( 2019)
ISSN: 1179-1322 [Print] New Zealand |
PMID | 31572001
(Publication Type: Journal Article)
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Copyright | © 2019 Wang et al. |