The use of antiserotonergic agents for the treatment of acute hemorrhagic shock of cats.

Abstract

In cats anesthetized with pentobarbitone sodium the effect of two types of antiserotonergic agents on cardiovascular recuperation after acute hemorrhage was examined. Methysergide, a competitive inhibitor for 5-HT receptors and p-chlorophenylalanine (PCPA), an inhibitor of tryptophan-5-hydroxylase, improved blood pressure recovery after bleeding. After extensive hemorrhage (40 ml/kg blood), treatment with methysergide improved survival. It is proposed that serotonin participates in the depressor response and survival of acute hypovolemic hypotension.

• Authors: R Elam, F Bergmann, G Feuerstein
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 107 Issue 2 Pg. 275-8 (Jan 02 1985) ISSN: 0014-2999 [Print] Netherlands
• PMID: 3156748 (Publication Type: Journal Article)

Chemical References

• Serotonin Antagonists
• Fenclonine
• Methysergide

Topics

• Animals
• Blood Pressure (drug effects)
• Body Temperature (drug effects)
• Cats
• Female
• Fenclonine (pharmacology)
• Heart Rate (drug effects)
• Male
• Methysergide (pharmacology)
• Serotonin Antagonists (therapeutic use)
• Shock, Hemorrhagic (drug therapy, physiopathology)