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Clinical response of a patient with diffuse histiocytic lymphoma to adoptive chemoimmunotherapy using cyclophosphamide and alloactivated haploidentical lymphocytes. A case report and phase I trial.

Abstract
Adoptive chemoimmunotherapy has cured experimentally induced tumors in animals, but its clinical use has been limited. Six patients were treated with refractory neoplasms in a Phase I study with cyclophosphamide (CPM) and alloactivated haploidentical lymphocytes. Patients received an immunosuppressive dose of CPM (800 mg/m2) followed by haploidentical lymphocytes primed in vitro with alloantigens in mixed lymphocyte culture (MLC). One week later patients received a second infusion of alloactivated lymphocytes expanded in T-cell growth factor (TCGF). The total number of cells given to each patient progressively increased, with a single patient receiving 35.5 X 10(9) cells. Transient febrile responses and delayed-type hypersensitivity reactions at the intravenous sites were the only toxicities noted. A complete clinical response lasting 12 weeks was seen in a single patient with diffuse histiocytic lymphoma. Our experience indicates that adoptive chemoimmunotherapy can be given to patients safely and merits further clinical testing.
AuthorsP C Kohler, J A Hank, R Exten, D Z Minkoff, D G Wilson, P M Sondel
JournalCancer (Cancer) Vol. 55 Issue 3 Pg. 552-60 (Feb 01 1985) ISSN: 0008-543X [Print] United States
PMID3155491 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • HLA Antigens
  • Interleukin-2
  • Isoantigens
  • Radioisotopes
  • Indium
  • Cyclophosphamide
Topics
  • Blood Transfusion
  • Cells, Cultured
  • Combined Modality Therapy
  • Cyclophosphamide (adverse effects, therapeutic use)
  • Evaluation Studies as Topic
  • Female
  • HLA Antigens (immunology)
  • Haploidy
  • Humans
  • Immunotherapy (methods)
  • Indium
  • Interleukin-2 (immunology)
  • Isoantigens (immunology)
  • Leukapheresis
  • Lymphocyte Activation
  • Lymphocyte Culture Test, Mixed
  • Lymphocyte Transfusion
  • Lymphocytes (immunology, ultrastructure)
  • Lymphoma, Large B-Cell, Diffuse (diagnostic imaging, therapy)
  • Male
  • Middle Aged
  • Radioisotopes
  • Radionuclide Imaging

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