Abstract |
Adoptive chemoimmunotherapy has cured experimentally induced tumors in animals, but its clinical use has been limited. Six patients were treated with refractory neoplasms in a Phase I study with cyclophosphamide (CPM) and alloactivated haploidentical lymphocytes. Patients received an immunosuppressive dose of CPM (800 mg/m2) followed by haploidentical lymphocytes primed in vitro with alloantigens in mixed lymphocyte culture (MLC). One week later patients received a second infusion of alloactivated lymphocytes expanded in T-cell growth factor ( TCGF). The total number of cells given to each patient progressively increased, with a single patient receiving 35.5 X 10(9) cells. Transient febrile responses and delayed-type hypersensitivity reactions at the intravenous sites were the only toxicities noted. A complete clinical response lasting 12 weeks was seen in a single patient with diffuse histiocytic lymphoma. Our experience indicates that adoptive chemoimmunotherapy can be given to patients safely and merits further clinical testing.
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Authors | P C Kohler, J A Hank, R Exten, D Z Minkoff, D G Wilson, P M Sondel |
Journal | Cancer
(Cancer)
Vol. 55
Issue 3
Pg. 552-60
(Feb 01 1985)
ISSN: 0008-543X [Print] United States |
PMID | 3155491
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- HLA Antigens
- Interleukin-2
- Isoantigens
- Radioisotopes
- Indium
- Cyclophosphamide
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Topics |
- Blood Transfusion
- Cells, Cultured
- Combined Modality Therapy
- Cyclophosphamide
(adverse effects, therapeutic use)
- Evaluation Studies as Topic
- Female
- HLA Antigens
(immunology)
- Haploidy
- Humans
- Immunotherapy
(methods)
- Indium
- Interleukin-2
(immunology)
- Isoantigens
(immunology)
- Leukapheresis
- Lymphocyte Activation
- Lymphocyte Culture Test, Mixed
- Lymphocyte Transfusion
- Lymphocytes
(immunology, ultrastructure)
- Lymphoma, Large B-Cell, Diffuse
(diagnostic imaging, therapy)
- Male
- Middle Aged
- Radioisotopes
- Radionuclide Imaging
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