Abstract | BACKGROUND AND PURPOSE: METHODS: The records of all adult patients admitted in three medical centres with MOG- IgG-associated ON who underwent orbital and brain magnetic resonance imaging (MRI) at the acute phase were reviewed. Spinal cord MRI within 1 month from the ON and all of the follow-up MRI were reviewed. RESULTS: Of 62 patients, 41.9% had bilateral ON and 66.2% optic disc swelling. On initial MRI, lesions were anterior (92%), extensive (63%) and associated with optic perineuritis (46.6%). Silent brain lesions were found in 51.8% of patients but were mainly non-specific (81%). Of 39 individuals with spinal MRI at onset, nine had abnormal findings (four were asymptomatic). Two symptomatic patients had longitudinally extensive myelitis with concurrent H-sign. At last follow-up, 5% of patients had visual acuity ≤0.1. Brain MRI remained unchanged in 41 patients (87%). CONCLUSIONS: Our study supports a mostly benign ophthalmological course of MOG- IgG-associated ON, despite initially longitudinally extensive lesions and development of optic nerve atrophy on orbital MRI. Spinal MRI could be of interest in detecting silent suggestive lesions.
|
Authors | N Shor, J Aboab, E Maillart, A Lecler, C Bensa, G Le Guern, S Grunbaum, R Marignier, C Papeix, E Heron, O Gout, J Savatovsky, D Galanaud, C Vignal, V Touitou, R Deschamps |
Journal | European journal of neurology
(Eur J Neurol)
Vol. 27
Issue 2
Pg. 384-391
(02 2020)
ISSN: 1468-1331 [Electronic] England |
PMID | 31532865
(Publication Type: Journal Article, Multicenter Study)
|
Copyright | © 2019 European Academy of Neurology. |
Chemical References |
- Autoantibodies
- Myelin-Oligodendrocyte Glycoprotein
|
Topics |
- Adult
- Autoantibodies
- Follow-Up Studies
- Humans
- Myelin-Oligodendrocyte Glycoprotein
- Myelitis
- Optic Neuritis
(diagnostic imaging)
|