Abstract | BACKGROUND: Several therapeutics have been proposed for neurotrophic keratitis, but no direct comparison among different approaches is available. OBJECTIVE: To compare treatment-related problems and outcomes of both traditional and novel therapeutics for neurotrophic keratopathy, focusing on resolution rate, healing time, and recurrence rate. DATA SOURCES: Literature search of published studies between 1980 and 2019 on neurotrophic keratopathy available on PubMed was made without any language constraints but limited to human study participants. STUDY SELECTION: All published peer-reviewed open, blinded and randomized clinical trials, case series and case reports, divided according to evidence level, were reviewed and resolution rate, healing time, relapses of the disease, and visual outcomes were evaluated. DATA EXTRACTION AND SYNTHESIS: Single observer data extraction. MAIN OUTCOMES AND MEASURES: resolution rate, healing time, recurrence rate. RESULTS: CONCLUSIONS AND RELEVANCE: Several new treatment options are available for patients with neurotrophic keratitis with adequate safety.
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Authors | Antonio Di Zazzo, Marco Coassin, Giuseppe Varacalli, Emanuela Galvagno, Antonio De Vincentis, Stefano Bonini |
Journal | The ocular surface
(Ocul Surf)
Vol. 17
Issue 4
Pg. 619-623
(10 2019)
ISSN: 1937-5913 [Electronic] United States |
PMID | 31526824
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2019. Published by Elsevier Inc. |
Chemical References |
- Ophthalmic Solutions
- Recombinant Proteins
- Nerve Growth Factor
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Topics |
- Amnion
(transplantation)
- Cornea
(innervation)
- Humans
- Keratitis
(etiology, therapy)
- Nerve Growth Factor
(administration & dosage)
- Ophthalmic Solutions
- Recombinant Proteins
- Tears
(metabolism)
- Treatment Outcome
- Trigeminal Nerve Diseases
(complications)
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