[Effect of interferon on the number of cytogenetic disorders occurring in human cultured lymphocytes treated with thio-TEPA and fotrin].

Abstract

The paper deals with the modifying effects of natural (leukocytic) and synthesized (recombinant) interferons on the number of cytogenetic injuries in the cultured lymphocytes of human peripheric blood after exposure to alkylating chemicals--thio-TEPA and fotrin. The analysis of chromosomal aberration levels is suggestive of a significant protective effect exerted by interferons. The addition of the recombinant interferon increased the number of sister chromatid exchanged frequency in mutagen treated variants. The application of the test system that involves two types of interferon made it possible to reveal differences in their cytogenetic effect during the protector-sensitive period of cultivation.

• Authors: T F Sarkisian, E S Movsesian, R M Arutiunian, G D Zasukhina
• Journal: Tsitologiia (Tsitologiia) Vol. 30 Issue 12 Pg. 1491-4 (Dec 1988) ISSN: 0041-3771 [Print] Russia (Federation)
• Vernacular Title: Vliianie interferona na kolichestvo tsitogeneticheskikh narusheniĭ, voznikaiushchikh v kul'tiviruemykh limfotsitakh cheloveka pri obabotke tioTEF i fotrinom.
• PMID: 3150139 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Aziridines
• Azirines
• Interferon Type I
• Mutagens
• Recombinant Proteins
• fotrin
• Thiotepa

Topics

• Aziridines (pharmacology)
• Azirines (pharmacology)
• Cells, Cultured
• Chromosome Aberrations
• Drug Interactions
• Humans
• Interferon Type I (pharmacology)
• Lymphocytes (drug effects, ultrastructure)
• Mutagens (pharmacology)
• Recombinant Proteins
• Sister Chromatid Exchange (drug effects)
• Thiotepa (pharmacology)