Abstract | UNLABELLED: CONTROL: 54.0 +/- 6.4%, p less than 0.01 and p less than 0.01, respectively] and area of gross myocardial hemorrhage ( AA-861: 5.1 +/- 2.4% of IS, ONO-1078: 5.2 +/- 2.5% vs CONTROL: 22.3 +/- 3.9%, p less than 0.01 and p less than 0.01, respectively). Both drugs also decreased frequency of ventricular premature contractions both during occlusion and during reperfusion, and that of ventricular tachycardia during reperfusion. AA-861 inhibited PMNs recruitment into infarcted area. However, ONO-1078 had no significant influence on degree of PMNs infiltration. These results suggest that lipoxygenase products, especially peptidoleukotrienes ( LTC4, D4 and E4) may play important roles in the pathogenesis of myocardial ischemic and reperfusion injuries.
|
Authors | Y Toki, N Hieda, T Torii, H Hashimoto, T Ito, K Ogawa, T Satake |
Journal | Prostaglandins
(Prostaglandins)
Vol. 35
Issue 4
Pg. 555-71
(Apr 1988)
ISSN: 0090-6980 [Print] United States |
PMID | 3150113
(Publication Type: Journal Article)
|
Chemical References |
- Benzoquinones
- Chromones
- Lipoxygenase Inhibitors
- Quinones
- SRS-A
- 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone
- pranlukast
|
Topics |
- Animals
- Arrhythmias, Cardiac
(prevention & control)
- Benzoquinones
- Cell Movement
(drug effects)
- Chromones
(therapeutic use)
- Dogs
- Hemodynamics
(drug effects)
- Hemorrhage
(prevention & control)
- Lipoxygenase Inhibitors
- Male
- Myocardial Infarction
(complications, drug therapy, pathology)
- Myocardial Reperfusion Injury
(prevention & control)
- Neutrophils
(drug effects)
- Quinones
(therapeutic use)
- SRS-A
(antagonists & inhibitors)
|