Rational treatment of refractory epilepsy in childhood.

A multifaceted study on childhood refractory epilepsy disclosed an insufficient classification of epilepsies and epileptic seizures, and inappropriate polypharmacy as the most important factors preventing appropriate therapy. By means of an adjustment of AEDs based on the accurate classification of epilepsies and epileptic seizures, the number of AEDs could be reduced in 37.5% and monotherapy was successful in 13.8% of refractory cases. Most of the latter were those of partial epilepsy and generalized epilepsy with the monoseizure type. The exacerbation of seizures due to AEDs was also mentioned as one of the important side effects of AEDs.
AuthorsY Ohtsuka, T Ogino, R Amano, Y Yamatogi, E Oka, S Ohtahara
JournalThe Japanese journal of psychiatry and neurology (Jpn J Psychiatry Neurol) Vol. 42 Issue 3 Pg. 443-7 (Sep 1988) ISSN: 0912-2036 [Print] JAPAN
PMID3149360 (Publication Type: Journal Article)
Chemical References
  • Anticonvulsants
  • Adolescent
  • Anticonvulsants (therapeutic use)
  • Child
  • Child, Preschool
  • Drug Therapy, Combination
  • Epilepsies, Partial (drug therapy)
  • Epilepsy (diagnosis, drug therapy)
  • Epilepsy, Temporal Lobe (drug therapy)
  • Female
  • Humans
  • Infant
  • Male
  • Spasms, Infantile (drug therapy)

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