Arginine 2-mercaptoethane sulfonate and sodium 2-mercaptoethane sulfonate: a comparative study of their effects upon tumour cells.

Abstract

The action of arginine 2-mercaptoethane sulfonate in comparison with sodium 2-mercaptoethane sulfonate on cell growth and cell adhesion of a metastatic sub-line of murine melanoma (F10/B16) was investigated. The capability of the two compounds to interfere with the cytotoxicity of 4-hydroperoxycyclophosphamide and of cis-dichlorodiammineplatinum(II) in F10 cells was studied. The in vivo studies included the determination of acute and sub-acute toxicity of the two salts on mice. Very low toxicity and no significant differences between the two compounds were detected.

• Authors: G Magnolfi Zipoli, S D'Ancona, T Berti
• Journal: Drugs under experimental and clinical research (Drugs Exp Clin Res) Vol. 14 Issue 7 Pg. 473-8 ( 1988) ISSN: 0378-6501 [Print] Switzerland
• PMID: 3149236 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Mercaptoethanol
• arginine 2-mercaptoethane sulfonate
• Arginine
• Mesna

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Arginine (analogs & derivatives, pharmacology, toxicity)
• Cell Division (drug effects)
• Cell Line
• Drug Screening Assays, Antitumor
• Male
• Melanoma, Experimental
• Mercaptoethanol (analogs & derivatives)
• Mesna (analogs & derivatives, pharmacology, toxicity)
• Mice
• Tumor Cells, Cultured (drug effects)