Relationships between endogenous CYP3A markers and plasma amlodipine exposure and metabolism in early postpartum and non-peripartum women with hypertension.

Abstract

OBJECTIVE:

This study aimed to evaluate the relationship between endogenous CYP3A markers and plasma amlodipine (AML) exposure and metabolism parameters in early postpartum and non-peripartum women.

METHODS:

Twenty-four AML-treated early postpartum women with hypertensive disorders of pregnancy and 30 non-peripartum women with essential hypertension were enrolled. Blood samples for determination of CYP3A markers including total cholesterol-adjusted 4β-hydroxycholesterol (4β-OHC/TC), 25-hydroxyvitamin D (25-OHD), and AML and its metabolites in plasma were collected at 24 h after the AML treatment.

RESULTS:

The plasma 4β-OHC/TC in postpartum women was higher than that in non-peripartum women, while the plasma 25-OHD was lower. The postpartum women had a lower plasma AML concentration and its metabolic ratio was higher. The plasma 4β-OHC/TC decreased as the number of days post-delivery increased. The plasma AML concentration increased as the number of days post-delivery increased, while the metabolic ratio of AML declined slightly. Tendency toward negative correlations between the plasma 4β-OHC/TC but not 25-OHD, and AML concentration were observed in both postpartum and non-peripartum women. In both groups, the plasma 4β-OHC/TC was correlated with the metabolic ratio of AML.

CONCLUSIONS:

The early postpartum women had higher plasma 4β-OHC and AML metabolism. The plasma 4β-OHC had positive relationships with amlodipine metabolism in both women groups. AML metabolism and plasma 4β-OHC may be useful as CYP3A markers in early postpartum and non-peripartum women.

• Authors: Reina Taguchi, Takafumi Naito, Naoko Kubono, Noriyoshi Ogawa, Hiroaki Itoh, Junichi Kawakami
• Journal: Pregnancy hypertension (Pregnancy Hypertens) Vol. 17 Pg. 209-215 (Jul 2019) ISSN: 2210-7797 [Electronic] Netherlands
• PMID: 31487643 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright © 2019 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

Chemical References

• Antihypertensive Agents
• Biomarkers
• Amlodipine
• Cytochrome P-450 CYP3A

Topics

• Administration, Oral
• Adult
• Aged
• Aged, 80 and over
• Amlodipine (administration & dosage, therapeutic use)
• Antihypertensive Agents (administration & dosage, therapeutic use)
• Biomarkers (blood)
• Case-Control Studies
• Cytochrome P-450 CYP3A (blood)
• Female
• Humans
• Hypertension (blood, drug therapy)
• Middle Aged
• Peripartum Period
• Pre-Eclampsia (blood, drug therapy)
• Pregnancy
• Pregnancy Complications, Cardiovascular (blood, drug therapy)
• Prenatal Care
• Young Adult