HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Multiple cytokine activities and loss of interleukin 2 inhibitor in synovial fluids of patients with rheumatoid arthritis.

Abstract
Attempts to detect immune mediators in rheumatoid arthritis synovial fluids (RA-SF) by bioassays have yielded conflicting results, and so we analyzed the immune reactions occurring within rheumatoid joints using monospecific immunoassays for cytokines such as interleukin 1 beta (IL-1 beta), interleukin 2 (IL-2) and gamma interferon (gamma-IFN). Furthermore, we examined the IL-2 inhibitors to clarify the immunoregulatory mechanism in the lesion. SF from active RA contained a significant amount of IL-1 beta and IL-2 but not gamma-IFN. In contrast IL-2 inhibitor activity was depressed in RA-SF regardless of clinical disease activity. Our results suggest that cytokine overproduction and deficiency of inhibitory signals may result in the overactivity of cytokines and the overactivity may participate in the joint lesions of RA.
AuthorsN Yamagata, K Kobayashi, T Kasama, T Fukushima, M Tabata, I Yoneya, Y Shikama, S Kaga, M Hashimoto, K Yoshida
JournalThe Journal of rheumatology (J Rheumatol) Vol. 15 Issue 11 Pg. 1623-7 (Nov 1988) ISSN: 0315-162X [Print] Canada
PMID3148711 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Interleukin-1
  • Interleukin-2
  • Lymphokines
  • interleukin 2 inhibitor
  • Interferon-gamma
Topics
  • Antibodies, Monoclonal
  • Arthritis, Rheumatoid (metabolism)
  • Cell Line
  • Humans
  • Immunoassay
  • Interferon-gamma (metabolism)
  • Interleukin-1 (metabolism)
  • Interleukin-2 (metabolism)
  • Lymphokines (metabolism)
  • Middle Aged
  • Synovial Fluid (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: