LncRNA LOXL1-AS is up-regulated in thoracic aortic aneurysm and regulated proliferation and apoptosis of aortic smooth muscle cells.

Abstract

Long non-coding RNA LOXL1-AS is up-regulated in several types of cancers. The present study was carried out to explore the potential interactions between LOXL1-AS and lncRNA Giver in thoracic aortic aneurysm (TAA). We found that LOXL1-AS was up-regulated in TAA patients than in healthy controls in aortic media specimens. Altered expression levels of LOXL1-AS distinguished TAA patients from healthy controls. LncRNA Giver was also up-regulated in TAA patients than in healthy controls in aortic media specimens, and was positively correlated with LOXL1-AS. LOXL1-AS overexpression mediated the up-regulation of Giver in human aortic smooth muscle cells, while Giver overexpression failed to significantly affect LOXL1-AS. LOXL1-AS and Giver overexpression resulted in promoted proliferation and inhibited apoptosis of HAOSMC. Giver silencing played an opposite role and attenuated the effect of LOXL1-AS overexpression. Therefore, LOXL1-AS was up-regulated in TAA and regulated proliferation and apoptosis of LOXL1-AS by up-regulating Giver.

• Authors: Ben Huang, Shuyang Lu, Hao Lai, Jun Li, Yongxin Sun, Chunsheng Wang
• Journal: Bioscience reports (Biosci Rep) Vol. 39 Issue 9 (09 30 2019) ISSN: 1573-4935 [Electronic] England
• PMID: 31471532 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 The Author(s).

Chemical References

• RNA, Long Noncoding
• Amino Acid Oxidoreductases
• LOXL1 protein, human

Topics

• Adult
• Amino Acid Oxidoreductases (genetics)
• Aorta (metabolism, pathology)
• Aortic Aneurysm, Thoracic (genetics, pathology)
• Apoptosis (genetics)
• Cell Proliferation (genetics)
• Cells, Cultured
• Female
• Gene Expression Regulation (genetics)
• Humans
• Male
• Middle Aged
• Myocytes, Smooth Muscle (metabolism, pathology)
• RNA, Long Noncoding (genetics)
• Transcriptional Activation (genetics)