Laparoscopy versus laparotomy approach of a radical resection for gallbladder cancer: a retrospective comparative study.

Abstract

BACKGROUND:

Laparoscopic approach for gallbladder cancer (GBC) has long been contraindicated, but few recent studies have demonstrated the oncologic outcomes of this treatment. The purpose of this study was to compare the perioperative outcomes and long-term survival for laparoscopic surgery versus traditional open surgery of GBC.

METHOD:

Between January 2014 and December 2018, 63 GBC patients who received radical resection were enrolled in this study, with 32 patients in laparoscopic group and 31 cases in laparotomy group. Perioperative data and postoperative survival were retrospectively evaluated.

RESULTS:

Laparoscopic approach was associated with less intraoperative bleeding (267.20 ± 47.07 vs. 502.60 ± 69.70, P = 0.007), fewer postoperative days of oral diet recovery (2.34 ± 0.31 vs. 3.32 ± 0.35, P = 0.041), and hospital stay (11.03 ± 0.99 vs. 14.35 ± 1.11, P = 0.028). There were no significant differences between two groups regarding other perioperative outcomes. Patients in laparoscopic group showed better 1-year overall survival than those in laparotomy group (72.91% vs. 47.82%, P = 0.086). Subgroup analysis for GBC patients in T3 stages revealed that laparoscopic approach was associated with less intraoperative bleeding (268.00 ± 57.19 vs. 541.50 ± 101.30, P = 0.009), fewer postoperative days of hospital stay (9.87 ± 1.10 vs. 14.90 ± 1.53, P = 0.017), and improved 1-year overall survival (P = 0.023). Subgroup analysis for GBCs in TNM III and TNM IV stages showed comparable intraoperative parameters and postoperative survival between two groups.

CONCLUSION:

Laparoscopic surgery for GBCs may offer the comparable perioperative outcomes as conventional laparotomy procedure, and tend to be associated with less intraoperative bleeding, faster oral diet recovery, shorter hospital stay, and improved 1-year overall survival.

• Authors: Changwei Dou, Yuhua Zhang, Jie Liu, Fangqiang Wei, Hongwu Chu, Junjun Han, Qifeng Yao, Jianyi Ding, Chengwu Zhang
• Journal: Surgical endoscopy (Surg Endosc) Vol. 34 Issue 7 Pg. 2926-2938 (07 2020) ISSN: 1432-2218 [Electronic] Germany
• PMID: 31463723 (Publication Type: Comparative Study, Journal Article)

Topics

• Adult
• Aged
• Cholecystectomy, Laparoscopic (methods)
• Female
• Gallbladder Neoplasms (mortality, pathology, surgery)
• Humans
• Laparoscopy (methods)
• Laparotomy (methods)
• Length of Stay
• Male
• Middle Aged
• Neoplasm Recurrence, Local
• Postoperative Complications (etiology)
• Retrospective Studies
• Treatment Outcome