Abstract |
Amphotericin B methyl ester, a water-soluble derivative of amphotericin B, is an experimental antifungal agent. Intravitreous injection of 5 and 10 micrograms of amphotericin B methyl ester in the normal rabbit eye does not cause toxic changes that can be detected clinically, microscopically, or by electroretinography. A single intravitreous injection of 5 micrograms was effective in reversing the course of exogenous Candida fungal endophthalmitis when administered within five days after inoculation of the infecting organism.
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Authors | J J McGetrick, G A Peyman, M A Nyberg |
Journal | Ophthalmic surgery
(Ophthalmic Surg)
Vol. 10
Issue 7
Pg. 25-9
(Jul 1979)
ISSN: 0022-023X [Print] United States |
PMID | 314613
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Amphotericin B
(therapeutic use, toxicity)
- Animals
- Candidiasis
(drug therapy)
- Disease Models, Animal
- Endophthalmitis
(drug therapy, pathology)
- Injections
- Mycoses
(drug therapy)
- Rabbits
- Vitreous Body
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