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Amphotericin B methyl ester: evaluation for intravitreous use in experimental fungal endophthalmitis.

Abstract
Amphotericin B methyl ester, a water-soluble derivative of amphotericin B, is an experimental antifungal agent. Intravitreous injection of 5 and 10 micrograms of amphotericin B methyl ester in the normal rabbit eye does not cause toxic changes that can be detected clinically, microscopically, or by electroretinography. A single intravitreous injection of 5 micrograms was effective in reversing the course of exogenous Candida fungal endophthalmitis when administered within five days after inoculation of the infecting organism.
AuthorsJ J McGetrick, G A Peyman, M A Nyberg
JournalOphthalmic surgery (Ophthalmic Surg) Vol. 10 Issue 7 Pg. 25-9 (Jul 1979) ISSN: 0022-023X [Print] United States
PMID314613 (Publication Type: Journal Article)
Chemical References
  • Amphotericin B
Topics
  • Amphotericin B (therapeutic use, toxicity)
  • Animals
  • Candidiasis (drug therapy)
  • Disease Models, Animal
  • Endophthalmitis (drug therapy, pathology)
  • Injections
  • Mycoses (drug therapy)
  • Rabbits
  • Vitreous Body

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